********************************************************************************
*                          pk.turnover.emax4.mlxtran                           *
*                          May 15, 2022 at 18:05:30                            *
*                          Monolix version : 2021R1                            *
********************************************************************************


ESTIMATION OF THE POPULATION PARAMETERS ________________________________________

Fixed Effects ----------------------------    se_lin    rse(%)
ktr_pop        :                      1.27     0.232      18.3
ka_pop         :                      1.04      0.13      12.5
cl_pop         :                     0.134   0.00712       5.3
v_pop          :                      7.73     0.344      4.45
emax_pop       :                     0.988   0.00721      0.73
ec50_pop       :                      1.05     0.108      10.3
kout_pop       :                    0.0536   0.00151      2.81
e0_pop         :                      96.7      1.12      1.16

Standard Deviation of the Random Effects -
omega_ktr      :                     0.732     0.141      19.2
omega_ka       :                     0.508    0.0952      18.8
omega_cl       :                     0.282    0.0391      13.9
omega_v        :                     0.224    0.0344      15.4
omega_emax     :                     0.829     0.845       102
omega_ec50     :                     0.514     0.079      15.4
omega_kout     :                    0.0788    0.0296      37.6
omega_e0       :                     0.052    0.0101      19.5

Correlations -----------------------------
corr_ec50_emax :                     0.787     0.522      66.4

Error Model Parameters -------------------
pkadd__err     :                     0.528    0.0629      11.9
prop__err      :                    0.0985    0.0115      11.7
pdadd__err     :                      3.77     0.246      6.54

Elapsed time (seconds):       54
CPU time     (seconds):  1.3e+02
Exploratory phase iterations:      250 (Fixed number of iterations)
Smoothing phase iterations:        200 (Fixed number of iterations)

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ESTIMATION OF THE INDIVIDUAL PARAMETERS ________________________________________


Estimation of the individual parameters by Conditional Distribution ------------
             min        Q1    median        Q3       max
ktr  :      0.36      1.13      1.26      1.52      3.13
ka   :     0.395     0.962      1.06      1.13      2.05
cl   :    0.0756     0.109      0.13     0.162     0.274
v    :      5.08      6.62      8.05      8.84      11.8
emax :     0.969     0.982     0.988     0.992     0.996
ec50 :     0.404     0.714      1.06      1.51      2.36
kout :     0.048    0.0514    0.0536    0.0556     0.059
e0   :      88.6      93.3      98.2      99.7       103

Elapsed time (seconds):      9.6
CPU time     (seconds):       22
Iterations:       78 (Autostop)

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Estimation of the individual parameters by Conditional Mode --------------------
             min        Q1    median        Q3       max
ktr  :     0.341      1.14      1.27      1.44      2.58
ka   :     0.401     0.963      1.06      1.14      1.92
cl   :     0.076      0.11     0.131     0.163      0.27
v    :      5.05      6.72      7.95      8.75      11.6
emax :     0.969     0.982     0.988     0.992     0.996
ec50 :     0.435     0.717      1.07      1.55      2.37
kout :    0.0482    0.0516    0.0532    0.0554    0.0587
e0   :      88.5      93.5      98.7      99.6       104

Elapsed time (seconds):      1.2
CPU time     (seconds):        3

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 _______________________________________________________________________________



ESTIMATION OF THE FISHER INFORMATION MATRIX ____________________________________


Estimation of the Fisher information matrix by Linearization -------------------

Correlation Matrix :
       ktr_pop         1
        ka_pop   0.06075         1
        cl_pop -0.025704 -0.020539         1
         v_pop-0.0041943-0.0026761  0.060501         1
      emax_pop-0.0017788  0.012958 0.0088989 -0.010087         1
      ec50_pop 0.0087976 0.0088681 -0.037985   0.01526   0.48124         1
      kout_pop -0.012882 -0.031036 -0.038045  0.084798  -0.49443 -0.085725         1
        e0_pop-0.00053549 0.0084347-0.0086088  0.010924 0.0025688 -0.049859   0.10704         1
     omega_ktr         0         0         0         0         0         0         0         0         1
      omega_ka         0         0         0         0         0         0         0         0  -0.07788         1
      omega_cl         0         0         0         0         0         0         0         0-0.0011648-0.00046592         1
       omega_v         0         0         0         0         0         0         0         0-0.0010056-0.00065819 -0.024088         1
    omega_emax         0         0         0         0         0         0         0         0-0.0048392-0.0023953-0.00235110.00044608         1
corr_ec50_emax         0         0         0         0         0         0         0         0 0.00336720.00068081  0.001203-0.0021029  -0.53044         1
    omega_ec50         0         0         0         0         0         0         0         0-0.0015698-0.0019776-0.0022852-0.00062815   0.29435   0.19158         1
    omega_kout         0         0         0         0         0         0         0         00.00044933-6.9662e-05-0.00045048 -0.009093  -0.17559   0.20713-0.0050353         1
      omega_e0         0         0         0         0         0         0         0         0 0.0014276-0.000162479.3522e-050.00073115  0.007667-0.00558340.00072051  0.019792         1
    pkadd__err         0         0         0         0         0         0         0         00.00026316  0.001221 -0.018113-0.0010423-0.0075787-0.0050976 -0.016426-0.0093848 0.0023305         1
     prop__err         0         0         0         0         0         0         0         0 -0.011235 -0.013554-0.0029729 -0.045621-0.0095284  0.013547 0.00132910.00014198-0.00036007  -0.58254         1
    pdadd__err         0         0         0         0         0         0         0         0 -0.010149-0.0057036-0.0014489-0.0043582 -0.058109  0.062607 -0.027127  -0.23783  -0.16233 -0.022699 0.0038067         1

                               min       max   max/min
Eigen values           :       0.3       1.7       5.8

Elapsed time (seconds):    0.084
CPU time     (seconds):        0

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 _______________________________________________________________________________



ESTIMATION OF THE LOG-LIKELIHOOD _______________________________________________

                                                           (lin)
-2 x log-likelihood                       (OFV) :        2409.63
Akaike Information Criteria               (AIC) :        2449.63
Corrected Bayesian Information Criteria  (BICc) :        2508.80
Bayesian Information Criteria             (BIC) :        2478.95

Elapsed time                          (seconds) :           0.00
CPU time                              (seconds) :           0.00

 _______________________________________________________________________________

DATASET INFORMATION
Number of individuals: 32
Number of observations (obsid 1): 251
Number of observations (obsid 2): 232
Number of doses: 32

