AiES: Axon Integrity Evaluation System for Microscopy Images

Provides tools for the quantitative analysis of axon integrity in phase-contrast microscopy images. 'AiES' (Axon integrity Evaluation System) implements image pre-processing, adaptive thresholding, feature extraction, and support vector machine-based classification to compute indices such as the Axon Integrity Index (AII) and Degeneration Index (DI). Two built-in models are provided, and classifiers can be re-trained on user data. The package is designed for reproducible and automated analysis in neuroscience research.

Version: 1.0.0
Depends: R (≥ 3.6.0)
Imports: EBImage, e1071, stats, fs, utils, data.table, rstudioapi, tiff
Suggests: knitr, rmarkdown, tcltk, svDialogs
Published: 2026-11-02
DOI: 10.32614/CRAN.package.AiES
Author: Shinji Tokunaga ORCID iD [aut, cre], Masabumi Funakoshi [ctb], Toshiyuki Araki ORCID iD [ctb], National Center of Neurology and Psychiatry [cph]
Maintainer: Shinji Tokunaga <tokunaga at ncnp.go.jp>
BugReports: https://github.com/BreezyCave/AiES/issues
License: BSD_3_clause + file LICENSE
Copyright: 2025 National Center of Neurology and Psychiatry
URL: https://github.com/BreezyCave/AiES
NeedsCompilation: no
Citation: AiES citation info
Materials: README, NEWS
CRAN checks: AiES results

Documentation:

Reference manual: AiES.html , AiES.pdf
Vignettes: AiES Introduction (source, R code)

Downloads:

Package source: AiES_1.0.0.tar.gz
Windows binaries: r-devel: AiES_0.99.6.zip, r-release: AiES_0.99.6.zip, r-oldrel: AiES_0.99.6.zip
macOS binaries: r-release (arm64): AiES_0.99.6.tgz, r-oldrel (arm64): AiES_0.99.6.tgz, r-release (x86_64): AiES_0.99.6.tgz, r-oldrel (x86_64): AiES_0.99.6.tgz
Old sources: AiES archive

Linking:

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